Barrier for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Barrier for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Barrier for Dogs is indicated for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var canis. Barrier for Dogs is also indicated for the treatment and control of the following intestinal parasites species: Hookworms (Ancylostoma caninum) (Uncinaria stenocephala)， Roundworms (Toxocara canis) (Toxascaris leonina) and Whipworms (Trichuris vulpis).

Barrier for Dogs: For the first 30 minutes after application:Ensure that dogs cannot lick the product from application sites onthemselves or other treated dogs， and separate treated dogs fromone another and from other pets to reduce the risk of accidentalingestion. Ingestion of this product by dogs may cause seriousadverse reactions including depression， salivation， dilated pupils，incoordination， panting， and generalized muscle tremors. Inavermectin sensitive dogs， the signs may be more severe and mayinclude coma and death. Some dogs are more sensitive to avermectins due to a mutation inthe MDR1 gene. Dogs with this mutation may develop signs of severeavermectin toxicity if they ingest this product. The most common breedsassociated with this mutation include Collies and Collie crosses. Although there is no specific antagonist for avermectin toxicity， evenseverely affected dogs have completely recovered from avermectintoxicity with intensive veterinary supportive care.PRECAUTIONS: Do not dispense dose applicator tubes without completesafety and administration information. Use with caution in sick， debilitatedor underweight animals. The safety of Barrier for Dogs has not beenestablished in breeding， pregnant， or lactating dogs. The safe use of Barrierfor Dogs has not been established in puppies and dogs less than 7 weeksof age or less than 3 lbs. body weight. Barrier for Dogs has not beenevaluated in heartworm-positive dogs with Class 4 heartworm disease.