PROZINC (protamine zinc recombinant human insulin) is an injectable insulin for cats anddogs. PROZINC is an aqueous suspension of protamine zinc recombinant human insulin thatis indicated to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signsassociated with hyperglycemia in cats and dogs with diabetes mellitus.

Cats and dogs presenting with severe ketoacidosis， anorexia， lethargy， and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition isstabilized. As with all insulin products， careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. Glucocorticoids， progestogens， and certain endocrinopathies can have an antagonistic effect on insulin activity. Glucocorticoid and progestogen use should be avoided. The safety and effectiveness of PROZINC in breeding， pregnant， and lactating cats and dogs has not been evaluated. The safety and effectiveness of PROZINC in kittens and puppies has not been evaluated.

Talk to your veterinarian about any other drugs your cat or dog is taking before starting this medication.

PROZINC (protamine zinc recombinant human insulin) is for use in cats and dogs only. Keep out of the reach of children. Avoid contact with eyes. In case of contact， immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection， seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals. As with all insulin products， careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain andmaintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. The most common adverse reactions were lethargy， anorexia， hypoglycemia， vomiting， seizures， shaking (dogs only)， diarrhea， and ataxia. Many of the adverse reactions， such as lethargy， seizures， shaking (dogs only)， and ataxia， are associated with hypoglycemia. The safety and effectiveness of PROZINC in puppies， kittens， or breeding， pregnant， and lactating animals has not been evaluated. PROZINC is contraindicated during episodes of hypoglycemia and in animals sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC. For additional information， please see full prescribing information.